Monoclonal Anti-Human IgG1 antibody produced in mouse

Description

• General description: Monoclonal Anti-Human IgG1 (mouse IgG2a isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Human IgG consists of four subclasses (1-4) that can be recognized by antigen differences in their heavy chains. They constitute approximately 65, 25, 6 and 4% of the total IgG, respectively. Each subclass has different biological and physiochemical properties.
• Specificity: Human IgG consists of four subclasses (1-4) that can be recognized.
• Application: Monoclonal Anti-Human IgG1 antibody produced in mouse has been used in:direct hemagglutination(HA)hemagglutination inhibition(HAI) assaysenzyme linked immunosorbent assay (ELISA) immunofluorometric assay (IFMA)immunofluorescencecell-based assays for the detection of IgG subclasses of acetylcholine receptor (AChR) antibodies
• Biochem/physiol Actions: Human IgG1 is the predominant subclass of in vivo and in vitro produced anti-tetanus toxoid antibodies. Only IgG1 and IgG3 are capable of adherence to mononuclear phagocytes via Fc receptors (FcR). A disproportionate elevation of IgG1 has also been found in the cerebral spinal fluid of patients with multiple sclerosis.
• Physical form: The antibody is provided as ascites fluid with 0.1% sodium azide as a preservative.
• Storage and Stability: For continuous use, store at 0-5 °C. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.
• Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.