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MABF1032

Anti-NKG2D (CD314) Antibody, clone 1D11

clone 1D11, from mouse

Manufacturer: Sigma Aldrich

Synonym(S): NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D-activating NK receptor, CD314

Select a Size

Pack Size SKU Availability Price
200 μL MABF1032-200-μL In Stock ₹ 41,010.01

MABF1032 - 200 μL

₹ 41,010.01

In Stock

Quantity

1

Base Price: ₹ 41,010.01

GST (18%): ₹ 7,381.802

Total Price: ₹ 48,391.812

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1D11, monoclonal

species reactivity

human

packaging

antibody small pack of 25 μL

technique(s)

flow cytometry: suitableimmunohistochemistry: suitableimmunoprecipitation (IP): suitable

isotype

IgG1κ

NCBI accession no.

NP_001186734

Description

  • General description: NKG2-D type II integral membrane protein (UniProt: P26718; also known as Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D-activating NK receptor, CD314) is encoded by the KLRK1 (also known as D12S2489E, NKG2D) gene (Gene ID: 100528032) in human. NK cell receptor D is a homodimeric, disulfide-linked, single-pass type II membrane protein that can also form heterohexamers along with four subunits of HCST/DAP10. NK cell receptor D contains a cytoplasmic domain (aa 1-51), a transmembrane helical domain (aa 52-72), and an extracellular domain (aa 73-216). It functions as an activating and co-stimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. It provides both stimulatory and co-stimulatory innate immune responses on activated killer (NK) cells, leading to their cytotoxic activity. Also acts as a co-stimulatory receptor for T-cell receptor (TCR) in CD8+ T-cell-mediated adaptive immune responses by amplifying T-cell activation. NK cell receptor D is expressed in natural killer (NK) cells, CD8+ alpha-beta and gamma-delta T-cells. Its expression in NK cells is upregulated by interleukin 15 (IL15).
  • Specificity: Clone 1D11 detects NKG2-D type II integral membrane protein in human cells.
  • Immunogen: Whole NKL cells (aggressive cell line derived from human natural killer cell leukemia).
  • Application: Anti-NKG2D (CD314), clone 1D11, Cat. No. MABF1032, is a mouse monoclonal antibody that detects human NKG2-D type II integral membrane protein and has been tested for use in Flow Cytometry, Fluorescence Activated Cell Sorting (FACS), Immunohistochemistry, Immunoprecipitation, ECM Adhesion and Inhibit
  • Quality: Isotype testing: Identity Confirmation by Isotyping Test.Isotyping Analysis: The identity of this monoclonal antibody is confirmed by isotyping test to be mouse IgG1 .
  • Target description: 25.27 kDa calculated.
  • Physical form: Format: Purified
  • Other Notes: Concentration: Please refer to lot specific datasheet.

SAFETY INFORMATION

WGK

WGK 1