7060062
MilliporeSigma™ Calbiochem™ Cyclopamine, V. californicum
Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog signaling through direct interaction with Smo.
Manufacturer: Fischer Scientific
CAS Number: 4449-51-8
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Color
Off-white
Target Proteins
Hh signaling in Shh-light2 assay
Molecular Formula
C27H41NO2
Solubility
DMSO, EtOH, or DMF
Form
Solid
Description
97% by HPLC
CAS
4449-51-8
Formula Weight
411.6g/mol
Content And Storage
Protect from light
Other Options
Related Products
Description
- A cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities
- It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors
- A valuable tool for studying the involvement of shh signaling in the development of various tumors
- Tomatidine (Cat
- No
- 614350) can be used as a negative control
- Also available as a 10mm solution in Ethanol (Cat
- No
- 239806).