01-670-944
COX2 Mouse anti-Human, Rat, Clone: AS73, Invitrogen™
Manufacturer: Qorpak
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Case of 12 | 01-670-944-Case-of-12 | In Stock | ₹ 4,725.90 |
01-670-944 - Case of 12
In Stock
Quantity
1
Base Price: ₹ 4,725.90
GST (18%): ₹ 850.662
Total Price: ₹ 5,576.562
Antigen
COX2
Classification
Monoclonal
Concentration
1 mg/mL
Gene
PTGS2
Gene Alias
PTGS2, prostaglandin-endoperoxide synthase 2, prostaglandin G/H synthase, cyclooxygenase, COX-2, PHS-2, PGG/HS, PGHS-2, hCox-2
Host Species
Mouse
Purification Method
Protein A/G
Regulatory Status
RUO
Gene ID (Entrez)
29527, 5743
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Clone
AS73
Conjugate
Unconjugated
Gene Accession No.
P35354, P35355
Gene Symbols
PTGS2
Immunogen
Human Cycloxygenase 2
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- This antibody does not cross-react with human COX1
- Cyclooxygenase (COX), also known as prostaglandin H2 synthase and Prostaglandin endoperoxide synthase, is a key enzyme in the conversion of arachidonic acid to Prostaglandin H2
- Prostaglandin H2 is converted by other enzymes into inflammatory mediators prostaglandin (PG) D2, PGE2, PGF2a, PGI2 and Thromboxane A2
- Thus, COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activities
- There are two enzymes of COX, COX-1, and COX-2
- COX-1 is constitutively produced in many (most) cell types
- It is important in the gut for the production of prostaglandins, which inhibit gastric secretion
- It can be induced in monocytes, macrophages and other cells
- It is induced as part of the inflammatory response by Il-1beta and other cytokines
- It is induced by growth factors such as EGF and PDGF
- Expression is inhibited by glucorticosteroids such as cortisol and dexamethasone
- Lipopolysaccharide in bacterial infections induces the COX-2
- COX-2 is also found in elevated levels in synoviocytes from rheumatoid arthritis patients
- The discomforts of imflammation such as pain and swelling are largely due to the action of prostaglandins produced by COX-2.