VEGF Receptor 1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-673-465-Each-of-1 | In Stock | ₹ 65,904.50 |
01-673-465 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 65,904.50
GST (18%): ₹ 11,862.81
Total Price: ₹ 77,767.31
Antigen
VEGF Receptor 1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
FLT1
Gene Alias
AI323757; embryonic receptor kinase 2; Emrk2; FLT; FLT1; FLT-1; fms related tyrosine kinase 1; FMS-like tyrosine kinase 1; FMS-related tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FRT; i21; sFlt1; soluble VEGFR 1; sVEGFR 1; Tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor-1; vascular permeability factor receptor; VEGF R1; VEGFR1; VEGFR-1
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
2321
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin)
Concentration
0.4 mg/mL
Formulation
PBS with 1% BSA and 0.1% sodium azide; pH 7.6
Gene Accession No.
P17948
Gene Symbols
FLT1
Immunogen
Synthetic peptide derived from C-terminus of human FLT-1.
Quantity
1 mL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- This antibody is predicted to react with mouse and rat based on sequence homology
- Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min
- Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature
- A suggested positive control is placenta or angiosarcoma
- FLT1 (VEGFR1) is a receptor tyrosine kinase which plays a critical role in angiogenesis
- Active angiogenesis has been found to play important role in many pathological and physiological processes, such as tumor progression, diabetic retinopathy, rheumatoid arthritis and wound healing
- May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells
- Can promote endothelial cell proliferation, survival and angiogenesis in adulthood
- Its function in promoting cell proliferation seems to be cell-type specific
- Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro)
- Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.