EGFR Monoclonal Antibody (H11), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-674-042-Each-of-1 | In Stock | ₹ 59,096.00 |
01-674-042 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 59,096.00
GST (18%): ₹ 10,637.28
Total Price: ₹ 69,733.28
Antigen
EGFR
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7.4
Gene Accession No.
P00533, Q01279
Gene Symbols
EGFR
Immunogen
HC2 20 d2 cells.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG1 κ
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
H11
Conjugate
Unconjugated
Gene
EGFR
Gene Alias
2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
13649, 1956
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- MA1-12693 detects Epidermal Growth Factor Receptor in human samples
- MA1-12693 has been successfully used in FACS, immunofluorescence, immunoprecipitation, Western blot, and immunohistochemistry (paraffin) procedures
- Staining of formalin-fixed tissues requires digestion with protease xxv at 1 mg/mL in PBS for 5 minutes at 37oC
- Positive controls include A431 cells or placenta or squamous cell carcinoma
- Suitable for Western blotting of extracellular domain of EGFR
- The MA1-12693 immunogen is HC2 20 d2 cells
- EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors
- Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics
- EGFR is encoded by the EGFR gene located on chromosome 7 in humans
- EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4
- EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain
- Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.