HEF1 Monoclonal Antibody (2G9), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-674-895-Each-of-1 | In Stock | ₹ 44,544.50 |
01-674-895 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,544.50
GST (18%): ₹ 8,018.01
Total Price: ₹ 52,562.51
Antigen
HEF1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% sodium azide
Gene Accession No.
O35177, Q14511
Gene Symbols
NEDD9
Immunogen
Fusion protein, corresponding to amino acids 82-398 of Human HEF1.
Quantity
50 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1 κ
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot
Clone
2G9
Conjugate
Unconjugated
Gene
NEDD9
Gene Alias
Cas scaffolding protein family member 2; CAS2; CASL; CAS-L; cas-like docking; CASS2; Crk-associated substrate lymphocyte-specific protein; Crk-associated substrate related protein Cas-L; CRK-associated substrate-related protein; dJ49G10.2; dJ761I2.1; Enhancer of filamentation 1; Enhancer of filamentation 1 p55; HEF1; mEF1; Nedd9; NEDD-9; Neural precursor cell expressed developmentally down-regulated protein 9; neural precursor cell expressed, developmentally down-regulated 9; neural precursor cell expressed, developmentally down-regulated gene 9; p105; p130Cas-related protein; renal carcinoma antigen NY-REN-12
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
18003, 291044, 4739
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This antibody detects HEF1 in human, mouse, and rat samples
- This antibody does not recognize p130cas
- It has not been tested on Sin1
- This antibody mostly detects HEF1 localized at the focal adhesion sites
- HEF-1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis and oncogenic transformation
- The Cas family of docking proteins have been the subject of intense research because of their role in cell motility, growth, apoptosis and oncogenic transformation
- These proteins are substrates of focal adhesion kinase (FAK) and the Src family of tyrosine kinases two active targets for drug development
- HEF1 protein production increases levels of mRNA transcripts that encode proteins associated with motility, cell transformation and invasiveness, including several metalloproteinases, MLCK, p160ROCK and ErbBi
- HEF1 overproduction also mediates apoptosis in epithelial-derived cell lines, including MCF7 and HeLa cells
- Recent clinical studies at another institution have found that overexpression of BCAR1 (p130Cas), a related protein, is associated with tamoxifen resistance
- This highlights the importance of studying the role of this family of proteins in cancer prognosis.