01-675-955
ICAM-3 Monoclonal Antibody (MEM-171), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-675-955-Each-of-1 | In Stock | ₹ 25,943.50 |
01-675-955 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,943.50
GST (18%): ₹ 4,669.83
Total Price: ₹ 30,613.33
Antigen
ICAM-3
Classification
Monoclonal
Concentration
1.0 mg/mL
Formulation
PBS with 15mM sodium azide; pH 7.4
Gene Accession No.
P32942
Gene Symbols
ICAM3
Immunogen
Human granulocytes.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Immunoprecipitation
Clone
MEM-171
Conjugate
Unconjugated
Gene
ICAM3
Gene Alias
CD50; CDw50; ICAM3; ICAM-3; ICAM-R; Intercellular adhesion molecule 3; intercellular adhesion molecule-3
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3385
Content And Storage
4° C, do not freeze
Form
Liquid
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Description
- This antibody recognizes an epitope in the D2 domain of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes
- CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin
- Besides functioning as an adhesive molecule that mediates e.g
- the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation
- ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.