SLP76 Monoclonal Antibody (SLP-76/03), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-676-125-Each-of-1 | In Stock | ₹ 43,832.50 |
01-676-125 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,832.50
GST (18%): ₹ 7,889.85
Total Price: ₹ 51,722.35
Antigen
SLP76
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 15mM sodium azide; pH 7.4
Gene Accession No.
Q13094, Q60787
Gene Symbols
LCP2
Immunogen
Bacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Porcine
Product Type
Antibody
Isotype
IgG2b
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
SLP-76/03
Conjugate
Unconjugated
Gene
LCP2
Gene Alias
76 kDa tyrosine phosphoprotein; AI323664; BB161688; Lcp2; Lymphocyte cytosolic protein 2; lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa); lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD); SH2 domain-containing leukocyte protein of 76 kDa; SH2 domain-containing leukocyte protein of 76kD; SLP76; SLP-76; SLP-76 tyrosine phosphoprotein; twm
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
100511843, 16822, 3937
Content And Storage
4° C, do not freeze
Form
Liquid
Related Products
Description
- SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat
- The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice
- The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains
- The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation
- SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain
- A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein
- Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.