HTRA2 Monoclonal Antibody (196C429), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-676-449-Each-of-1 | In Stock | ₹ 47,481.50 |
01-676-449 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
HTRA2
Classification
Monoclonal
Conjugate
Unconjugated
Gene
HTRA2
Gene Alias
AI481710; High temperature requirement protein A2; HtrA serine peptidase 2; HtrA2; HtrA-like serine protease; mnd2; motor neuron degeneration 2; OMI; Omi stress-regulated endoprotease; PARK13; protease, serine, 25; Prss25; Serine protease 25; serine protease HTRA2, mitochondrial; serine protease OMI; serine proteinase OMI
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
27429
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
196C429
Formulation
PBS with 0.05% BSA and 0.05% sodium azide
Gene Accession No.
O43464
Gene Symbols
HTRA2
Immunogen
Synthetic peptide corresponding to residues 335-350 of human Htra2.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
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Description
- Suggested positive control: HL-60 or Jurkat whole cell lysate
- The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli
- All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3)
- Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli
- This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4)
- Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus
- The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.