SOX10 Monoclonal Antibody (20B7), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-592-380-Each-of-1 | In Stock | ₹ 15,041.00 |
14-592-380 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 15,041.00
GST (18%): ₹ 2,707.38
Total Price: ₹ 17,748.38
Antigen
SOX10
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
O55170, P56693, Q04888
Gene Symbols
SOX10
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
20665, 29361, 6663
Content And Storage
4° C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone
20B7
Conjugate
Unconjugated
Gene
SOX10
Gene Alias
cls; cls/sox10; colorless; colourless; colourless/sox10; DOM; dominant megacolon; dominant megacolon, mouse, human homolog of; golas; gos; HMG-box transcription factor Sox10; MGC15649; PCWH; Protein SOX-21; SOX10; Sox-10; sox10 protein; sox10b; Sox21; SOX9; SRY; SRY (sex determining region Y)-box 10; SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal); SRY box 10; SRY-box 10; SRY-box containing gene 10; SRY-box containing protein 10; SRY-box transcription factor 10; SRY-related HMG-box gene 10; transcription factor SOX-10; Transcription factor SOX-M; WS2E; WS4; WS4C; zgc:100757
Host Species
Mouse
Quantity
25 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description The MAb 20B7 recognizes Sox10, is a member of the Sox superfamily (SRY-related HMG-box) that contain a DNA binding domain (high-mobility group domain) and functions as a transcription factor
- Initially, Sox10 expression is localized to the developing neural crest and peripheral nervous system, but later is expressed in glial progenitors and mature oligodendrocytes
- Sox10 is involved in stem cell maintenance, melanocyte differentiation, as well as central and peripheral gliogenesis and neurogenesis
- Sox10 regulation of downstream proteins such as MASH1, PHOX2B, PDGF-alpha, and MITF is dependent on expression level
- Sox10 is also expressed in multipotent vascular stem cells, melanomas, and gliomas
- The 20B7 antibody is reported to recognize human and rat Sox 10, and based on homology should recognize mouse Sox10
- SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate
- This protein may act as a transcriptional activator after forming a protein complex with other proteins
- It acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development
- Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.