EZH2 Monoclonal Antibody (AC22), eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-986-782-Each-of-1 | In Stock | ₹ 40,050.00 |
14-986-782 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,050.00
GST (18%): ₹ 7,209.00
Total Price: ₹ 47,259.00
Antigen
EZH2
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q15910, Q61188
Gene Symbols
EZH2
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
14056, 2146, 312299
Content And Storage
4° C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Clone
AC22
Conjugate
Unconjugated
Gene
EZH2
Gene Alias
an; enhancer of zeste 2 polycomb repressive complex 2 subunit; enhancer of zeste homolog 2; enhancer of zeste homolog 2 (Drosophila); ENX 1; ENX1; Enx-1; Enx1h; EZH 2; EZH1; EZH2; EZH-2; EZH2b; histone-lysine N-methyltransferase EZH2; KMT6; KMT6A; lysine N-methyltransferase 6; mKIAA4065; OTTHUMP00000213774; OTTHUMP00000213778; OTTHUMP00000213779; OTTHUMP00000213780; WVS; WVS2
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG2a κ
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Description
- Description: The monoclonal antibody AC22 recognizes EZH2 (Enhancer of zeste homolog 2), a member of the polycomb group (PcG) proteins responsible for repression of gene expression through recognition and modification of histone methylation and chromatin structure
- EZH2 comprises the catalytic subunit of the polycomb repressive complex 2 (PRC2) and directly represses gene expression through methylation of histone H3 on lysine 27 (H3K27) as well as direct protein targets such as GATA4
- The PRC2 complex gene repression is necessary for proper development and differentiation
- Underexpression of EZH2 is linked to abnormal developmental patterning and a loss of stem cell pluripotency, while overexpression of EZH2 is present in many tumors and correlates with poor prognosis in melanoma, breast, and prostate cancer
- Applications Reported: This AC22 antibody has been reported for use in immunoprecipitation, western blotting, and immunocytochemistry
- Applications Tested: This AC22 antibody has been tested by immunocytochemistry of methanol-fixed cells and can be used at less than or equal to 5 μg/mL
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Purity: Greater than 90%, as determined by SDS-PAGE
- Aggregation: Less than 10%, as determined by HPLC
- Filtration: 0.2 μm post-manufacturing filtered
- EZH2 (Histone-lysine N-methyltransferase) is a member of the Polycomb-group (PcG) family
- PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations
- This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein
- EZH2 may play a role in the hematopoietic and central nervous systems
- Mutations affecting EZH2 can cause Weaver syndrome (WVS).