14-996-537
FOXJ1 Monoclonal Antibody (2A5), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-996-537-Each-of-1 | In Stock | ₹ 1,22,108.00 |
14-996-537 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,22,108.00
GST (18%): ₹ 21,979.44
Total Price: ₹ 1,44,087.44
Antigen
FOXJ1
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q61660, Q92949
Gene Symbols
FOXJ1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
15223, 2302
Content And Storage
4° C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
2A5
Conjugate
Unconjugated
Gene
FOXJ1
Gene Alias
FKHL13; FKHL-13; fork head homologue 4; forkhead box J1; forkhead box protein J1; forkhead transcription factor HFH-4; forkhead-like 13; forkhead-related protein FKHL13; Foxj1; Hepatocyte nuclear factor 3 forkhead homolog 4; Hfh4; HFH-4; HNF-3/forkhead homolog 4; MGC35202
Host Species
Mouse
Quantity
2 mg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- Description: This 2A5 monoclonal antibody reacts with Foxj1, a 50-kDa member of the Forkhead-box (FOX) family of winged-helix transcription factors
- Expression of Foxj1 is high in ciliated epithelial cells and low in naive T and B cells, where cellular activation results in downregulation of the factor
- Foxj1 modulates germinal center formation and Th1 activation by repressing NFkappaB through IkappaBbeta induction
- As such, this transcription factor has been suggested to antagonize autoimmune reactions such as systemic lupus erythematosus and rheumatoid arthritis
- In addition, Foxj1 has been linked to the formation of motile cilia in epithelial cells
- Applications Reported: This 2A5 antibody has been reported for use in western blotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, and immunocytochemistry
- Applications Tested: This 2A5 antibody has been tested by western blot of mouse tracheal epithelial cells and testes, as well as by immunohistochemistry of mouse lung tissue
- This antibody can be used between 1-10 μg/mL
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Purity: Greater than 90%, as determined by SDS-PAGE
- Aggregation: Less than 10%, as determined by HPLC
- Filtration: 0.2 μm post-manufacturing filtered
- Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and spontaneous autoimmunity, through the repression of NF B activity
- FOXJ1 also inhibits the humoral immune response in B cells
- FOXJ1 deficiency in B cells results in spontaneous and accentuated germinal center formation and is implicated in the development of pathogenic autoantibodies and accentuated responses to immunizations
- Abnormal expression of FOXJ1 may be associated with autoimmune diseases and/or other inflammatory diseases
- FOXJ1 is also required for cilia formation and left-right axis determination because it increases calpastatin expression, a protein necessary for the ability of basal bodies to anchor to the apical cytoskeleton
- FOXJ1 expression may function as an early marker of epithelial cell differentiation, recovery, and function.