CD85k (Gp49b) Monoclonal Antibody (H1.1), Functional Grade, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 16-578-4025-Each-of-1 | In Stock | ₹ 7,63,620.00 |
16-578-4025 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 7,63,620.00
GST (18%): ₹ 1,37,451.60
Total Price: ₹ 9,01,071.60
Antigen
CD85k (Gp49b)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7.2
Gene Accession No.
Q64281
Gene Symbols
Lilrb4a
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
14728
Content And Storage
4° C
Form
Liquid
Applications
Functional Assay, Neutralization
Clone
H1.1
Conjugate
Functional Grade
Gene
Lilrb4a
Gene Alias
CD85 antigen-like family member K; CD85K; glycoprotein 49 B; glycoprotein 49b; gp49; Gp49b; GP49B2; HM18; ILT3; ILT-3; Immunoglobulin-like transcript 3; leucocyte Ig-like receptor B4; leukocyte immunoglobulin like receptor B4; leukocyte immunoglobulin-like receptor 5; Leukocyte immunoglobulin-like receptor subfamily B member 4; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; leukocyte immunoglobulin-like receptor, subfamily B, member 4; leukocyte surface receptor; Lilrb4; LIR5; LIR-5; mast cell surface glycoprotein Gp49B; Monocyte inhibitory receptor HM18
Host Species
Armenian Hamster
Quantity
25 mg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The MAb H1.1 recognizes gp49, a receptor with structural similarities to the PIR (paired Ig-activating receptors) and ILT/KIR(killer inhibitory receptors) family of proteins
- Two closely linked genes on mouse chromosome 10 encode the related proteins gp49A and gp49B
- These two receptors are almost 90% identical in their extracellular regions but differ in their cytoplasmic domains; gp49B contains an ITAM domain while gp49A does not and is extremely short
- Expression of gp49 was originally identified on mast and LAK (IL-2 activated NK) cells
- Expression on LAK cells has been shown to be predominantly gp49B with only a small amount of gp49A
- Additionally gp49 is found on myeloid cells
- Detailed function is not known but gp49B can inhibit cellular activation
- The MAb H1.1 recognizes both gp49A and gp49B
- The H1.1 antibody has been shown to have functional activity: when crosslinked along with anti-NK1.1 it can prevent cytokine release in KY-2 cells
- This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4
- The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs)
- The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response
- The receptor can also function in antigen capture and presentation
- It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity
- Multiple transcript variants encoding different isoforms have been found for this gene
- [provided by RefSeq, Jul 2008].