IL-2 Monoclonal Antibody (AB12-3G4), Functional Grade, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 16-702-738-Each-of-1 | In Stock | ₹ 1,90,015.00 |
16-702-738 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,90,015.00
GST (18%): ₹ 34,202.70
Total Price: ₹ 2,24,217.70
Antigen
IL-2
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7.2
Gene Accession No.
P60568
Gene Symbols
IL2
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3558
Content And Storage
4° C
Form
Liquid
Applications
Functional Assay, Neutralization
Clone
AB12-3G4
Conjugate
Functional Grade
Gene
IL2
Gene Alias
aldesleukin; cytokine; H-IL-2; il 2; Il2; Il-2; ILN; Interleukin; interleukin 2; interleukin 2 precursor; interleukin 2 variant IL2delta2; Interleukin2; Interleukin-2; interleukin-2 precursor; interleukin-2 precursor protein; interleukin-2; interleukin 2; Involved in regulation of T cell clonal expansion; involved in regulation of T-cell clonal expansion; lymphokine; M-IL-2; patial sequence of Interleukin-2; POIL2; porcine Interleukin 2; T cell growth factor; T-cell growth factor; T-cell growth factor (TCGF); TCGF
Host Species
Mouse
Quantity
5 mg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a κ
Related Products
Description
- Description: This AB12-3G4 monoclonal antibody reacts with and inhibits the bioactivity of human IL-2
- IL-2 is a 15 kDa cytokine expressed by B cells, T cells, and dendritic cells
- IL-2 signals via a heterotrimeric receptor (CD25) and results in the activation of Jak/STAT pathways
- IL-2 plays a critical role in the proliferation, activation, and differentiation of T cells
- The development of CD4+CD25+ regulatory T cells is especially dependent on the presence of IL-2, making it an important immunoregulatory cytokine
- Applications Reported: This AB12-3G4 monoclonal antibody inhibits the bioactivity of human IL-2
- Applications Tested: The ND50 of AB12-3G4, as determined by the neutralization of Human IL-2-induced proliferation of the CTLL-2 cell line, is less than or equal to 60 ng/mL in the presence of 10 ng/mL Human IL-2 Recombinant Protein
- The neutralization dose of this antibody will vary depending on cell type, assay method, and cytokine concentration
- Storage and handling: Use in a sterile environment
- Filtration: 0.2 μm post-manufacturing filtered
- Purity: Greater than 90%, as determined by SDS-PAGE
- Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay
- Aggregation: Less than 10%, as determined by HPLC
- Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages
- IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7)
- The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene
- The targeted disruption of a gene similar to IL-2 in mice leads to an μgcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.