CD278 (ICOS) Monoclonal Antibody (C398.4A), APC, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 17-994-980-Each-of-1 | In Stock | ₹ 10,146.00 |
17-994-980 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 10,146.00
GST (18%): ₹ 1,826.28
Total Price: ₹ 11,972.28
Antigen
CD278 (ICOS)
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q9R1T7, Q9WVS0
Gene Symbols
ICOS
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
54167, 64545, 705788
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
C398.4A
Conjugate
APC
Gene
ICOS
Gene Alias
Activation-inducible lymphocyte immunomediatory molecule; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; CVID1; H4; Icos; inducible costimulator; inducible T cell costimulator; inducible T cell co-stimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; Ly115
Host Species
Armenian Hamster
Quantity
25 μg
Primary or Secondary
Primary
Target Species
Mouse, Rat, Rhesus Monkey
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Description: The C398.4A monoclonal antibody reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS
- ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family
- A dimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response
- ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1, is thought to play a protective role in inflammatory autoimmune diseases and be involved in the development of Th2 cells
- C398.4A is reported to display strong costimulation of proliferation of T cell clones, intermediate costimulation on activated T cells, and weak costimulation on fresh resting T cells
- It is a good costimulator of IL-10 production especially from pre-activated cells that express high level of H4/ICOS
- The epitope recognized by C398.4A is different from that bound by the ICOSL (i.e., C398.4A does not block binding of ICOSL)
- Applications Reported: This C398.4A antibody has been reported for use in flow cytometric analysis
- Applications Tested: This C398.4A antibody has been tested by flow cytometric analysis of Con A-stimulated mouse splenocytes
- This can be used at less than or equal to 0.125 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- CD278 (ICOS) Monoclonal antibody specifically detects CD278 (ICOS) in Mouse, Rat, Rhesus Monkey samples
- It is validated for Flow Cytometry.