HLA-B Monoclonal Antibody (C1), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
HLA-B
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
A29 protein, antigen presenting molecule, AS, Aw-33, Aw-74, B-4901, B-5001, Bw-47, Bw-50, class I MHC, HLA-B antigen, DAQB-90C11.16, epididymis secretory protein Li 83, FLJ26655, HEL-S-83, histocompatibility antigen, HLA A, HLA -B, HLA B-40011, HLA B44, HLA class I antigen, HLA class I antigen HLA-B, HLA class I histocompatibility antigen, A alpha chain, HLA class I histocompatibility antigen, A-1 alpha chain, HLA class I histocompatibility antigen, A-30 alpha chain, HLA class I histocompatibility antigen, A-33 alpha chain, HLA class I histocompatibility antigen, A-74 alpha chain, HLA class I histocompatibility antigen, B alpha chain, HLA class I histocompatibility antigen, B-47 alpha chain, HLA class I histocompatibility antigen, B-50 alpha chain, HLA class I histocompatibility antigen, B-82 alpha chain, HLA locus, HLA molecule, HLAA, HLA-A, HLA-A locus alpha 2 domain, HLA-A null, HLA-A11, HLA-A33, HLA-Aw33.1, HLAB, HLA-B, HLA-B 1502, HLA-B alpha chain, HLA-B alpha chain (B*2706), HLA-B alpha chain (B*5002), HLA-B alpha-chain, HLA-B*45ZJ, HLA-B15, HLA-B35, HLA-B35 antigen, HLA-B-3506, HLA-B39, HLA-B-3905, HLA-B49, HLA-B50, HLA-B55, HLA-B-5502, HLA-B-5602, HLA-B59, HLA-B61, HLA-Bw50 antigen, HLA-Cw, HLA-DQB1, HLA-DRB1, Human leukocyte antigen A, hypothetical protein, lecocyte antigen B, leukocyt, Leukocyte Antigen, leukocyte antigen class I-A, leukocyte antigen class I-B, Leukoocyte Antigen, lymphocyte antigen, major histocompatability complex B antigen, major histocompatibility complex, class I, A, major histocompatibility complex, class I, B, MCH class I antigen, MHC 1, MHC antigen, MHC class 1 antigen, MHC class I alpha chain, MHC class I anitgen, MHC class I anti, MHC Class I antigen, MHC class I antigen A*30, MHC class I antigen A*33, MHC class I antigen A*74, MHC class I antigen B*47, MHC class I antigen B*50, MHC class I antigen B*82, MHC class I antigen GN00104, MHC class I antigen heavy chain, MHC class I antigen HLA-A heavy chain, MHC class I antigen HLA-A33, MHC class I antigen HLA-B alpha chain, MHC class I antigen HLA-B heavy chain, MHC class I antigen null protein, MHC class I antigen SHCHA, MHC class I antigene, MHC class I human leukocyte antigen, MHC class I molecule, MHC class I protein, MHC class II antigen, MHC class l antigen, MHC classI antigen, MHC HLA-B cell surface glycoprotein, MHC HLA-B transmembrane glycoprotein, MHC HLA-B27d, MHC HLA-B27-HS, MHC HLA-B39N, MHC1, SPDA1, truncated class I antigen, truncated MHC class I antigen
Gene Symbols
HLA-B
Isotype
IgG2b κ
Purification Method
Protein A/G
Gene
HLA-B
Clone
C1
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
P01889
Gene ID (Entrez)
3106
Immunogen
Recombinant Human MHCB protein, Ser26-Val309 (Accession #P01889)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Related Products
Description
- HLA-B belongs to the HLA class I heavy chain paralogues
- This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin)
- The heavy chain is anchored in the membrane
- Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen
- They are expressed in nearly all cells
- The heavy chain is approximately 45 kDa and its gene contains 8 exons
- Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail
- Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule
- Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation
- Hundreds of HLA-B alleles have been described
- HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.