alpha-1 Antitrypsin Monoclonal Antibody (H8), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
alpha-1 Antitrypsin
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
a-1 AT, A1A, a1-antitrypsin, A1AT, AAT, Aat2, Aat-2, alpha 1 antitrypsin, alpha-1 antitrypsin, alpha-1 protease inhibitor, Alpha-1 protease inhibitor 1, alpha-1-antiproteinase, Alpha-1-antitrypsin, alpha-1-antitrypsin (protease inhibitor), alpha-1-antitrypsin 1-1, alpha-1-antitrypsin 2, alpha-1-antitrypsin null, alpha1AT, alpha-1-protease inhibitor, alpha-1-proteinase inhibitor, Digestive Zymogen, Dom1, MGC23330, MGC9222, PI, PI1, PRO0684, PRO2209, PRO2275, protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin, protease inhibitor 1 (anti-elastase, antitrypsin, alpha-1), Protease Serine 1, serine (or cysteine) peptidase inhibitor, clade A, member 1A, serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, serine (or cysteine) proteinase inhibitor, clade A (alpha-1antiproteinase, antitrypsin), member 1, serine (or cysteine) proteinase inhibitor, clade A, member 1, serine (or cysteine) proteinase inhibitor, clade A, member 1a, Serine Protease 1, serine protease inhibitor 1-1, Serine protease inhibitor A1a, serine protease inhibitor alpha 1, serine proteinase inhibitor, clade A, member 1, serpin A1, Serpin A1a, serpin family A member 1, serpin peptidase inhibitor clade A member 1, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, SERPINA1, Serpina1a, Short peptide from AAT, SPAAT, Spi1, Spi1-1, Spi1-3, TRP1, TRY1
Gene Symbols
SERPINA1, Serpina1a
Isotype
IgG1 κ
Purification Method
Protein A/G
Gene
SERPINA1
Clone
H8
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Mouse, Porcine, Rat
Gene Accession No.
P01009, P07758, P17475, P50447
Gene ID (Entrez)
20700, 24648, 397688, 5265
Immunogen
Recombinant Human a1AT protein, Glu25-Lys418 (Accession #P01009)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Related Products
Description
- Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung
- In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma
- Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn
- Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation
- Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.