200020116
VNN1 Monoclonal Antibody (C2), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
VNN1
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
HDLCQ8, Pantetheinase, pantetheine hydrolase, Tiff66, V-1, vanin 1, Vanin1, vanin-1, vannin 1, vascular non-inflammatory molecule 1, VNN1
Gene Symbols
VNN1
Isotype
IgG1 κ
Purification Method
Protein A/G
Gene
VNN1
Clone
C2
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Porcine
Gene Accession No.
O95497, Q9BDJ5
Gene ID (Entrez)
397246, 8876
Immunogen
Recombinant Human VNN1 protein, Gln22-Gly491 (Accession #O95497)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Related Products
Description
- Hematopoietic precursor cells migrate to the thymus, where they differentiate into mature T lymphocytes
- GPI-anchored vanin-1 protein regulates the late adhesion steps of thymus homing of bone marrow precursor cells
- Vanin-1 is ubiquitously expressed as a pantetheinase enzyme and catalyzes the hydrolysis of pantetheine for vitamin B5 recycling
- The hydrolytic activity of vanin-1 generates the potent antioxidant cysteamine as a metabolite
- As a membrane bound pantetheinase, vanin-1 provides the main source of cysteamine under normal physiological conditions
- In mice, vanin-1 is expressed specifically in male Sertoli cells of the developing testis, where it aids in cell migration.