200020330

Trypsin Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

Trypsin

Applications

Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Conjugate

Unconjugated

Host Species

Rabbit

Target Species

Human, Mouse, Porcine, Rat

Gene Accession No.

P00762, P07477

Gene ID (Entrez)

114228, 24691, 5644

Immunogen

Recombinant Human PRSS1 protein, Ser51-Val228 (Accession #P07477)

Primary or Secondary

Primary

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Concentration

0.5 mg/mL

Classification

Polyclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4

Gene Alias

Alpha-trypsin chain 1, Alpha-trypsin chain 2, Anionic trypsin I, anionic trypsin-1, Anionic trypsinogen, beta-trypsin, Cationic trypsinogen, digestive zymogen, MGC120175, MGC149362, nonfunctional trypsin 1, pancreatic trypsin 1, pretrypsinogen I, Protease Serine 1, protease serine 2 preproprotein, protease, serine 1, protease, serine 1 (trypsin 1), protease, serine 2, protease, serine, 1, protease, serine, 1 (trypsin 1), protease, serine, 2, protease, serine, 2 (trypsin 2), PRSS1, PRSS2, PTRYI, RATPTRYI, Serine protease 1, Serine protease 2, TCR V beta 4.1, TRP1, Try1, Try-1, TRY2, TRY4, TRY8, Trygn16, TRYP1, TRYP2, TRYP8, trypsin 1, Trypsin I, Trypsin II, trypsin-1, Trypsin-2, trypsinogen, trypsinogen 1, trypsinogen 16, trypsinogen 2, trypsinogen A

Gene Symbols

PRSS1

Isotype

IgG

Purification Method

Protein A

Gene

PRSS1

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Description

  • Trypsin is a 24 kDa enzyme of the serine proteinase family
  • It is produced in the pancreas as an inactive precursor, trypsinogen, but the active enzyme is located in the gastrointestinal tract where it degrades proteins to large peptides
  • Trypsin prefers lysine and arginine residues
  • One of the substrates for trypsin is chymotrypsinogen which is cleaved to produce active chymotrypsin
  • High levels of immunoreactive trypsin in the bloodstream can indicate pancreatic malfunction and this indicator is used to screene for and diagnose Cystic Fibrosis.