Arginase 1 Monoclonal Antibody (C7), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Arginase 1
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
AI, A-I, AI type I arginase, AI256583, Arg1, Arg-1, Arginase, arginase 1, arginase 1 liver, arginase 1, liver, arginase I, arginase, liver, Arginase1, arginase-1, HGNC:663, Liver Arginase, Liver-type arginase, PGIF, similar to arginase, type I, Type 1 Arginase, type I arginase
Gene Symbols
ARG1
Isotype
IgG1 κ
Purification Method
Protein A/G
Gene
ARG1
Clone
C7
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Porcine
Gene Accession No.
P05089, Q95JC8
Gene ID (Entrez)
383, 397115
Immunogen
Recombinant Human ARG protein, Met1-Lys322 (Accession #P05089)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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Description
- Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle
- The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation
- By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production
- In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells
- In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported
- In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a)
- Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas
- Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.