CX3CR1 Monoclonal Antibody (2A9-1), PE-Cyanine7, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 25-609-942-Each-of-1 | In Stock | ₹ 41,474.00 |
25-609-942 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,474.00
GST (18%): ₹ 7,465.32
Total Price: ₹ 48,939.32
Antigen
CX3CR1
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
P49238
Gene Symbols
CX3CR1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1524
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
2A9-1
Conjugate
PE-Cyanine7
Gene
CX3CR1
Gene Alias
Beta chemokine receptor-like 1; CCRL1; chemokine (C-C) receptor-like 1; chemokine (C-X3-C motif) receptor 1; chemokine (C-X3-C) receptor 1; CMKBRL1; CMK-BRL1; CMK-BRL-1; CMKDR1; Cx3c; CX3C chemokine receptor 1; C-X3-C CKR-1; C-X3-C motif chemokine receptor 1; Cx3cr1; Fractalkine receptor; G protein-coupled receptor 13; GPR13; G-protein coupled receptor 13; GPRV28; RBS11; Scyd1; V28
Host Species
Rat
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b κ
Related Products
Description
- This 2A9-1 MAb reacts with human CX3CR1, which is the receptor for fractalkine, a transmembrane chemokine of the CX3C family
- CX3CR1 is a seven transmembrane G protein-coupled receptor expressed on CD16+ NK cells, T cells (e.g
- CD8+, CD4+, and gamma/delta), and monocytes
- In non-immune cells, CX3CR1 has been found on osteoclast precursors and microglia
- Little to no CX3CR1 surface expression can be detected on B cells and granulocytes
- Together, fractalkine and its receptor mediate cell-cell adhesion and chemotaxis of NK cells, T cells, and monocytes
- The expression of CX3CR1 has also been correlated with high levels of intracellular perforin and granzyme B
- CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection
- The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively
- The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1
- Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine
- CX3CR1 mediates leukocyte migration an d adhesion
- CX3CR1 is expressed in a variety of human tissues and cell lines.