CD196 (CCR6) Monoclonal Antibody (sirx6), eFluor™ 660, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-8902-Each-of-1 | In Stock | ₹ 33,197.00 |
50-112-8902 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 33,197.00
GST (18%): ₹ 5,975.46
Total Price: ₹ 39,172.46
Antigen
CD196 (CCR6)
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
O54689
Gene Symbols
CCR6
Immunogen
N-terminal extracellular domain of mouse CCR6
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
Applications
Flow Cytometry
Clone
sirx6
Conjugate
eFluor 660
Gene
CCR6
Gene Alias
BN-1; CC chemokine receptor 6; C-C chemokine receptor type 6; C-C CKR-6; C-C motif chemokine receptor 6; CC-CKR-6; CCR6; CCR-6; CD196; chemokine (C-C motif) receptor 6; chemokine (C-C) receptor 6; chemokine receptor-like 3; CKR6; CKRL3; CKR-L3; Cmkbr6; DCR2; DRY6; DRY-6; G protein-coupled receptor 29; GPR29; GPRCY4; GPR-CY4; G-protein coupled receptor 29; KY411; LARC receptor; seven-transmembrane receptor, lymphocyte, 22; STRL22
Host Species
Rat
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12458
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
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Description
- Description: The sirx6 monoclonal antibody reacts with mouse CD196 (CCR6)
- CD196 is a seven transmembrane G protein-coupled receptor expressed on T, B, dendritic, NK and Langerhans cells
- This CC chemokine receptor uniquely binds MIP3a/CCL20, a chemoattractant for dendritic cells, effector/memory T cells, and B cells
- CD196 is also involved in host defense and inflammation at epithelial sites
- Furthermore, this receptor has been implicated in Th17 differentiation and CD4+FoxP3+ regulatory T cell development
- Due to expression characteristics of some chemokine receptors (shedding, surface cleavage or intracellular cycling), we recommend a fixation step after surface staining
- Refer to Applications Tested for more information
- Applications Reported: This sirx6 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This sirx6 antibody has been tested by flow cytometric analysis of mouse splenocytes
- Cells are surface stained, then washed with Flow Cytometry Staining Buffer, immediately fixed with IC Fixation Buffer for 20-30 minutes, and then washed with Flow Cytometry Staining Buffer prior to analysis
- This can be used at less than or equal to 1 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors
- The gene is preferentially expressed by immature dendritic cells and memory T cells
- The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha)
- This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses
- Alternatively spliced transcript variants that encode the same protein have been described for this gene.