36-008-CMI
MilliporeSigma™ Mouse anti-alpha-Synuclein (aa 121-125), (Ascites Free), Clone: Syn211,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 36-008-CMI-Each-of-1 | In Stock | ₹ 42,968.31 |
36-008-CMI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,968.31
GST (18%): ₹ 7,734.296
Total Price: ₹ 50,702.606
Antigen
alpha-Synuclein (aa 121-125), (Ascites Free)
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
SNCA; NACP; PARK1
Immunogen
Conjugated recombinant protein corresponding to human alpha-Synuclein.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_000336
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Immunohistochemistry, Western Blot
Clone
Syn211
Gene Accession No.
P37840
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
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Description
- Specifically detects alpha-Synuclein (aa 121-125), (Ascites Free) clone: Syn211 in Human samples, and it is validated for Immunohistochemistry, Western Blotting Alpha-synuclein is encoded by the SNCA gene (also known as NACP, PARK1) in human
- There are two other known synuclein family members, beta- and gamma-synuclein
- Interest in synuclein research started with the discovery of alpha-synuclein mutation in several families with autosomal dominant Parkinson's disease (PD)
- Alpha-synuclein is abundantly expressed in the brain and is found in a classic amyloid fibril form within the intra-neuronal Lewy body deposits of PD
- The physiological function of synucleins is not well understood, but appears to involve membrane interactions, and in particular reversible binding to synaptic vesicle membranes
- Contradictory evidences regarding inhibitory action of alpha-synuclein against phospholipase D (PLD) have been reported (PMID 11821392 & 19146388)
- Clone Syn211, detects epitope in the region from amino acid 121 to 125 and has been used together with clone LB509, to characterize the digestion pattern of different forms of in vitro prepared alpha-synclulein aggregates (Guo, J.L., et al
- 2013; PMID 23827677).