3851590
Carboxypeptidase E Mouse, Unlabeled, Clone: 35, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Carboxypeptidase E
Concentration
250μg/mL
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Cell Biology
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype
IgG1
Purification Method
Affinity Purified
Clone
35
Applications
Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Human, Mouse, Rat
Immunogen
Human Carboxypeptidase E aa. 49-200
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
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Description
- Carboxypeptidase E (CPE), also known as carboxypeptidase H and enkephalin convertase, is found as both a membrane-bound and a soluble glycoprotein in neuroendocrine tissues and adrenal-gland chromaffin granules
- The C-terminus forms an amphiphilic α-helix, suggesting that this region is responsible for the membrane-bound form
- Evidence suggests the active form of CPE is located in the secretory vesicles
- CPE appears to have several functions
- It is an exopeptidase that cleaves neuropeptides with C-terminal basic amino acids, producing an active form of the peptide
- It has also been proposed that membrane-bound CPE is a sorting receptor for regulated secretory pathway (RSP) proteins in the TGN pituitary Golgi and secretory granule membranes
- RSP proteins primarily consist of hormones and neuropeptides
- Mice that carry a mutation in the CPE gene Cpe[fat] display endocrine disorders such as obesity, infertility, and hyperproinsulinemia
- Furthermore, the same endocrine disorders are observed in Cpe[fat] mice where the CPE gene has been effaced by antisense RNA
- Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting