3853339
CD123 Mouse anti-Human, PerCP-Cy5.5, Clone: 7G3, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD123
Applications
Flow Cytometry
Conjugate
PerCP-Cyanine5.5
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG2a κ
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Clone
7G3
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Immunogen
Human IL-3Ra-transfected cells
Primary or Secondary
Primary
Description
IL3RA; IL-3RA; IL-3Rα; IL-3R-alpha; Interleukin-3 receptor subunit alpha
Related Products
Description
- Reacts with human CD123, the 70 kD IL-3 receptor α chain (IL-3Rα), which associates with the 120-140kDa β subunit
- The β chain is shared with the receptors for interleukins IL-5 and GM-CSF
- IL-3Rα is expressed on hematopoietic progenitors
- This antibody has been reported to block the binding of 125I-IL-3 to high and low affinity IL-3 receptors
- In functional experiments, this antibody was found to inhibit acute myeloid leukemia cell proliferation, basophil histamine release, endothelial cell-mediated IL-8 secretion, and neutrophil transmigration
- This antibody has been reported to be useful for immunoprecipitation, western blot and immunofluorescent staining for flow cytometry
- IL-3Rα plays an important role in hematopoietic progenitor cell growth and differentiation
- At the Fifth HLDA Workshop, the human IL-3 receptor was designated CD123
- Flow Cytometry