3855824
γ-Catenin Mouse, Unlabeled, Clone: 15, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
γ-Catenin
Concentration
250μg/mL
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Cell Biology
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype
IgG2a
Purification Method
Affinity Purified
Clone
15
Applications
Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Canine, Chicken, Human, Mouse, Rat
Immunogen
Human γ-Catenin aa. 553-738
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
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Description
- γ-Catenin (plakoglobin) was identified as a compenent of desmosomes where it associates with desmoglein
- γ-Catenin and β-Catenin are closely related proteins that have significant homology with the Drosophila armadillo protein
- In addition to complexing with E-Cadherin, γ-Catenin and β-Catenin have been observed in association with the intracellular domain of N-Cadherin
- It has been proposed that one molecule of α-Catenin and at least one molecule of β-Catenin and γ-Catenin simultaneously bind to a single cadherin molecule
- A 19 amino acid sequence of desmoglein (Dsg1) was found to be critical for binding of γ-Catenin
- This region has significant homology to the catenin-binding domain of classical cadherins, thus suggesting a common mechanism for γ-Catenin localization at both adherens junctions and desmosomes
- Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting