3970150
CD8 Mouse anti-Human, APC-H7, Clone: SK1, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD8
Applications
Flow Cytometry
Conjugate
APC-H7
Regulatory Status
RUO
Target Species
Baboon, Cynomolgus, Human, Rhesus Monkey
Immunogen
Human Peripheral Blood T Cells
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Clone
SK1
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Immunology
Formulation
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
CD8α; CD8A; CD8 alpha; Leu2a; MAL; T8; p32
Related Products
Description
- CD8 recognizes the 32kDa a-subunit of a disulfide-linked bimolecular complex
- The majority of peripheral blood CD8+ T lymphocytes express an a/b heterodimer (Mr 32, 30kDa), while CD8+CD16+ natural killer (NK) lymphocytes and CD8+ T-cell receptor (TCR)-γ/δ+ lymphocytes express a/a homodimer (Mr 30kDa)
- CD8+TCR-α/β+ lymphocytes can express either an α/α homodimer or α/β heterodimer
- The CD8 antigenic determinant binds to class I major histocompatibility (MHC) molecules resulting in increased adhesion between the CD8+ T lymphocytes and target cells
- Binding of the CD8 antigen is coupled to a protein tyrosine kinase p56lck
- The CD8:p56lck complex can play a role in T-lymphocyte activation through mediation of the interactions between the CD8 antigen and the CD3/TCR complex
- Host Species: Mouse Clone: SK1 Isotype: IgG1 κ Species Reactivity: Human Immunogen: Human Peripheral Blood T Cells Flow Cytometry