Cyclin A Mouse anti-Human, Unlabeled, Clone: 25, BD

Description

• Progression of the mammalian cell cycle is regulated by phosphorylation of many key proteins
• Several classes of cyclins (A-E) act as regulatory subunits for cyclin-dependent kinases (cdks)
• These cyclin-cdk holoenzymes are essential for proper control of cell cycle progression
• They phosphorylate and regulate a variety of substrates whose activity is required for cell cycle transitions
• The temporal expression of cyclins is tightly regulated throughout the cell cycle by synthesis and degradation
• Such regulation plays a critical role in controlling the enzymatic activity of the cdks
• Cyclin A, one of the mitotic cyclins, activates Cdk2 near the start of S phase and is necessary for the initiation of DNA replication
• In mammalian somatic cells, Cyclin A is required during S phase and passage through G2
• The D and E type cyclins regulate passage through G1, while Cyclin B is a critical regulator of mitosis
• It has been shown in a number of species that mutation or disruption of normal Cyclin A expression causes cells to arrest at G2
• Cyclin A binds both the cdc2 (Cdk1) and Cdk2 kinases and may also have a role in mitotic dependence on S phase completion
• Host Species: Mouse Clone: 25 Isotype: IgG1 Species Reactivity: Human Immunogen: Human Cyclin A aa
• 26-144 Formula Weight [Chemical]: 60kDa Bioimaging, Immunofluorescence, Western Blotting