Cyclin D1 Mouse anti-Human, Unlabeled, Clone: G124-326, BD

Description

• Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes
• Cyclins contain a conserved amino acid sequence motif, the cyclin box, which allows their binding to cdks to form active complexes that regulate the progression of the cell cycle
• The synthesis and degradation of cyclins is tightly controlled in a cell cycle specific manner
• Several classes of cyclins (A-E) have been described
• Cyclins have been placed into functional groups as follows: Group 1 (cyclins A, B, D1, D2, D3, E and F) functions primarily in cell cycle reguation; Group 2 (cyclins C and H) also plays a role in transcriptional regulation; Group 3 (cyclins G1, G2 and I) may play a role distinct from other cyclins
• Specific substrates for cyclin-cdk complexes include nuclear lamins, histones, oncogenes (c-src, c-abl, SV40 large-T Ag), tumor suppressor genes (Rb and p53), and others
• The D-type cyclins are involved in regulating the passage of mammalian cells through G1
• The reduced molecular weights of cyclin D1 is ∽36kda
• G124-326 recognizes human cyclin D1 and cross-reacts with the mouse homolog (Cyl1) of human cyclin D1
• It does not cross-react with human cyclins D2 and D3
• Recombinant full-length human cyclin D1 was used as immunogen
• Host Species: Mouse Clone: G124-326 Isotype: IgG1 Species Reactivity: Human Immunogen: Recombinant full-length human cyclin D1 Formula Weight [Chemical]: 36kDa Flow Cytometry, Immunoprecipitation, Western Blotting