FAK Mouse, Unlabeled, Clone: 77/FAK, BD

Description

• Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that colocalizes with integrins in focal adhesions
• This cellular localization is directed by a 125 amino acid sequence at the C-terminus called the “Focal Adhesion Targeting sequence” (FAT)
• The binding of extracellular matrix ligands to integrins triggers autophosphorylation and activation of FAK
• This creates binding sites for SH2 domains of intracellular signaling molecules such as src, PI3 kinase, and Grb2
• FAK's ability to bind numerous structural and signaling proteins via a variety of interactions has led to substantial speculation about its function
• Although FAK's precise role has not been elucidated, proposed possibilities include regulating cell motility, cell growth, cytoskeletal organization, and adhesion-dependent cell survival
• Host Species: Mouse Clone: 77 Isotype: IgG1 Species Reactivity: Human Immunogen: Chicken FAK aa
• 354-533 Formula Weight [Chemical]: 116-125kDa Bioimaging, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting