3971693
Paxillin Mouse, Unlabeled, Clone: 349, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Paxillin
Concentration
1.0mg/mL
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Cell Biology
Formulation
Aqueous buffered solution containing glycerol and ≤0.09% sodium azide.
Isotype
IgG1
Purification Method
Affinity Purified
Clone
349
Applications
Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Canine, Chicken, Human, Mouse, Rat
Immunogen
Chicken Paxillin aa. 1 to 557
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
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Description
- A number of cytoskeletal proteins are tyrosine phosphorylated in Rous sarcoma virus-transformed chick embryo fibroblasts
- One of these is the 68 kDa paxillin protein
- Paxillin is a cytoskeletal component that localizes to the focal adhesions at the ends of actin stress fibers
- It is also present in the focal adhesions of Madin-Darby canine kidney epithelial cells, but is absent from the cell adherens junctions of these cells
- Paxillin purified from chicken gizzard migrates as a diffuse band on SDS-PAGE with molecular weight of 65-70 kDa
- It binds to the rod domain of vinculin, another focal adhesion protein
- It is thought that phosphorylation of paxillin may have a role in that disassembly of focal adhesions and stress fibers during transformation.