4358228
CD86 Mouse anti-Human, Brilliant Violet 421, Clone: 2331 (FUN-1), BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD86
Applications
Flow Cytometry
Conjugate
Brilliant Violet 421
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
B7.2; B7-2; B-lymphocyte activation antigen B7-2; B70; BU63; CD28LG2; LAB72
Clone
2331 (FUN-1)
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Immunogen
Human HBL-1 Cell Line
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The 2331 (FUN-1) monoclonal antibody specifically recognizes a 75 kDa transmembrane cell surface protein, CD86 (B70/B7-2), expressed primarily on monocytes, dendritic cells and activated B cells
- Competitive binding assays demonstrate that, while both 2331 (FUN-1) and IT2.2 (anti-CD86, Cat
- No
- 555663) antibodies specifically recognize the same molecule, they react with different epitopes
- CD86 is the second ligand for CD28 and CTLA-4 and may play an important role in co-stimulation of T cells in primary immune response
- The 2331 (FUN-1) antibody blocks the costimulatory activity of CD86 when tested in functional studies.The antibody was conjugated to Brilliant Violet 421 and has been developed in collaboration with Sirigen
- With an Ex Max of 407-nm and Em Max at 421-nm, Brilliant Violet 421 can be excited by the violet laser and detected in the standard Pacific Blue filter set (eg, 450/50-nm filter)
- Brilliant Violet 421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates
- Host Species: Mouse Clone: 2331 (FUN-1) Isotype: IgG1, κ Species Reactivity: Human Flow Cytometry