4543459
Epredia™ Lab Vision™ HER-2/c-erbB-2/neu Rabbit Monoclonal Antibody supernatant
Recommended for Immunohistochemistry (Formalin/paraffin), Epredia™ HER-2/c-erbB-2/neu, Rabbit Monoclonal Antibody is part of a comprehensive antibody portfolio. Studies show rabbit monoclonal antibodies are more sensitive and specific than other available markers.
Manufacturer: Fischer Scientific
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Antigen
HER-2/c-erbB-2/neu
Applications
Immunohistochemistry
Host Species
Rabbit
Primary or Secondary
Primary
Clone
EP1045Y
Conjugate
Unconjugated
Immunogen
A synthetic peptide corresponding to the c-terminus of human Her2
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Description
- HER2 gene encodes a transmembrane glycoprotein with tyrosine kinase activity
- It is closely related in structure to the epidermal growth factor receptor c-erbB-3/HER3/neu oncoprotein
- The protein is detectable in a subset of breast and other carcinomas (urinary bladder, stomach, lung, endometrium and ovary)
- In the case of breast cancer, over expression determined by immunohistochemistry has been shown to be associated with poor prognosis and an indication to initiate trastuzumab/herceptin therapy
- Host Species: Rabbit Clone: EP1045Y Isotype: IgG Species Reactivity: Human
- Others not tested
- Epitope: Not determined Immunogen: A synthetic peptide corresponding to the c-terminus of human Her2 Molecular Weight: 185 kDa Positive Control: Breast carcinomas Cellular Localization: Cell membrane Recommended for: Immunohistochemistry (Formalin/paraffin)