VISTA Monoclonal Antibody (MH5A), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 46-591-982-Each-of-1 | In Stock | ₹ 38,448.00 |
46-591-982 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,448.00
GST (18%): ₹ 6,920.64
Total Price: ₹ 45,368.64
Antigen
VISTA
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q9D659
Gene Symbols
VSIR
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
74048
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
MH5A
Conjugate
PerCP-eFluor 710
Gene
VSIR
Gene Alias
4632428N05Rik; B7H5; B7-H5; C10orf54; C1H10orf54; C28H10orf54; C4H10orf54; chromosome 10 open reading frame 54; DD1alpha; Death Domain1alpha; Dies1; differentiation of ESCs 1; GI24; PD-1H; PDCD1 homolog; PD-H1; platelet receptor Gi24; PP2135; RIKEN cDNA 4632428N05 gene; SISP1; sisp-1; Stress-induced secreted protein-1; UNQ730/PRO1412; V-domain Ig suppressor of T cell activation; VISTA; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation
Host Species
Armenian Hamster
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The MAb MH5A reacts with a homolog of PD-1 (PD-1H) also known as VISTA
- PD-1H is a 309 aa type I transmembrane protein that belongs to the CD28 superfamily
- This cell surface receptor is expressed on nearly all hematopoietic cells except B cells
- VISTA negatively regulates T cell responses by suppressing early TCR activation, inhibiting cell proliferation, and suppressing TH1 cytokine production
- The MH5A antibody has been reported to inhibit T cell infiltration in graft-versus-host disease mouse models
- VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene
- Although VISTA bears sequence homology to PD-L1 it has a different expression pattern
- In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells with the highest densities on myeloid cells, and lower levels on T cells
- It is usually absent on B cells
- VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy
- The reported ligands of VISTA include CD28H, VSIG-3 and VSIG-8.