ROR gamma (t) Monoclonal Antibody (AFKJS-9), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 46-698-882-Each-of-1 | In Stock | ₹ 21,805.00 |
46-698-882 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 21,805.00
GST (18%): ₹ 3,924.90
Total Price: ₹ 25,729.90
Antigen
ROR gamma (t)
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide, pH 7.2
Gene Accession No.
P51449, P51450
Gene Symbols
Rorc
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
19885, 6097, 717052
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
AFKJS-9
Conjugate
PerCP-eFluor 710
Gene
Rorc
Gene Alias
EGK_01272, IMD42, MGC129539, NR1F3, nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, nuclear receptor subfamily 1 group F member 3, RAR related orphan receptor C, RAR-related orphan nuclear receptor variant 2, RAR-related orphan receptor C, RAR-related orphan receptor C, isoform a, RAR-related orphan receptor gamma, retinoic acid-binding receptor gamma, retinoid-related orphan receptor gamma, retinoid-related orphan receptor-gamma, ROR Gamma, ROR gamma t, Rorc, Rorg, RORgamma, RORgt, RP11-98D18.11-001, RZRG, RZR-GAMMA, Thor, Thymus orphan receptor, TOR
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rhesus Monkey
Product Type
Antibody
Isotype
IgG2a κ
Related Products
Description
- Description: The AFKJS-9 monoclonal antibody reacts with the mouse, human and rhesus monkey RORgamma(t) protein
- RORgamma is a member of the retinoic acid-related orphan receptor (ROR) family, which also includes RORalpha and RORbeta
- ROR family proteins are ligand-dependent transcription factors that play roles in multiple physiological processes
- RORgamma is expressed in several tissues including liver, lung, muscle, heart and kidney
- Furthermore, it was discovered that alternative transcription results in the expression of an isoform, RORgamma(t), which is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ double-positive thymocytes, Th17 cells of the periphery and lymphoid tissue inducer (LTi) cells of lymphoid organs
- The RORgamma(t) isoform differs from RORgamma by three unique amino acids at its amino terminus
- Therefore, the AFKJS-9 antibody will react with both the RORgamma and RORgamma(t) isoforms
- Applications Reported: This AFKJS-9 antibody has been reported for use in intracellular staining followed by flow cytometric analysis
- Applications Tested: This AFKJS-9 antibody has been tested by intracellular staining followed by flow cytometric analysis of mouse thymocytes using the Foxp3/Transcription Factor Staining Buffer Set (Product No
- 00-5523-00) and protocol
- ROR gamma, a NR1 Thyroid Hormone-Like receptor, has been shown to affect thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis
- ROR gamma has been shown to promote thymocyte survival by activating the expression of the antiapoptotic protein Bcl-x(L)
- ROR gamma is also required for the development of lymph nodes and Peyer's patches
- It has been shown that ROR gamma(t), a thymus-specific isoform of ROR gamma from mouse, inhibits Fas ligand expression and cytokine secretion in immature thymocytes
- ROR gamma binds as a monomer to response elements composed of a single core motif, GGTCA, preceded by a 6 bp AT-rich sequence
- ROR gamma expression has been documented in mouse thymus, adipose, bone, skeletal muscle, liver, and kidney, and in human skeletal muscle
- ESTs have been isolated from human tissue libraries, including cancerous head/neck, germ cell, and prostate, and normal colon, head/neck, lung, liver/spleen, and pancreas
- ROR gammat t (RORgt) is an isoform of RORC.