IL-23 p19 Monoclonal Antibody (23dcdp), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 46-782-342-Each-of-1 | In Stock | ₹ 41,563.00 |
46-782-342 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,563.00
GST (18%): ₹ 7,481.34
Total Price: ₹ 49,044.34
Antigen
IL-23 p19
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
Q9NPF7
Gene Symbols
IL23A
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
51561
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
23dcdp
Conjugate
PerCP-eFluor 710
Gene
IL23A
Gene Alias
il 23; IL 23 A; IL12B; Il-12b; Il12p40; Il-12p40; il23; IL-23; IL-23 subunit alpha; IL23A; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; Interleukin; interleukin 12B; interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; MGC79388; P19; p40; RP23-388G23.1; SGRF; UNQ2498/PRO5798
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b κ
Related Products
Description
- This 23dcdp MAb reacts with the p19 subunit of human IL-23
- This heterodimeric cytokine is composed of two disulfide-linked subunits, p40 and p19
- It is closely related to IL-12, with which it shares the p40 subunit
- The IL-23 receptor is also heterodimeric and shares the IL-12R\beta1 chain with IL-12, while the IL-23R chain is unique to the IL-23 receptor complex
- IL-23R signaling occurs through the Jak/STAT pathway and results in ROR\gammat expression, which promotes maintenance and proliferation of T helper 17 (Th17) cells
- Dendritic cells and macrophages produce IL-23 in response to TLR2, TLR4, and TLR8 ligands, as well as agonists of the \beta-glucan receptor, Dectin-1
- Our studies suggest donor, kinetics and type of stimulant can result in variation in IL-23 expression levels
- Recent publications suggest the p19 subunit may also exist in the absence of association with p40
- IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19
- p19, like p35 of IL-12, is biologically inactive by itself
- IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R
- IL-23 is secreted by activated mouse and human dendritic cells
- Biological activities of mouse IL-23 are distinct from those of mouse IL-12
- Mouse IL-23 was found not to induce significant amounts of IFN-γ
- Mouse IL-23 does induce strong proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells
- Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17
- Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN-γ production by naive and memory T cells, as compared to IL-12.