IL-37 Monoclonal Antibody (37D12), PE, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each | 50-112-2391-Each | In Stock | ₹ 31,118.85 |
50-112-2391 - Each
In Stock
Quantity
1
Base Price: ₹ 31,118.85
GST (18%): ₹ 5,601.393
Total Price: ₹ 36,720.243
Antigen
IL-37
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
Q9NZH6
Gene Symbols
IL37
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
27178
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
37D12
Conjugate
PE
Gene
IL37
Gene Alias
FIL1; FIL1 zeta; FIL1(ZETA); FIL1Z; IL-1 zeta; IL1F7; IL-1F7; IL1F7 (canonical product IL-1F7b); IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL-1H; IL1H4; IL-1H4; IL1RP1; IL-1RP1; IL-1X; IL-1X protein; IL37; IL-37; ILN; Interleukin; interleukin 1 family member 7; interleukin 1, zeta; interleukin 37; Interleukin-1 family member 7; Interleukin-1 homolog 4; interleukin-1 superfamily z; Interleukin-1 zeta; Interleukin-1-related protein; interleukin-23; Interleukin37; Interleukin-37
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description: This 37D12 monoclonal antibody reacts with human IL-37
- IL-37 is a member of the interleukin 1 cytokine family and is also known as IL-1F7 and IL-1H4
- IL-37 suppresses innate inflammatory and immune responses and exhibits anti-inflammatory characteristics resembling those of IL-1R8
- IL-37 binds to the alpha chain of IL-18R with low affinity and does not recruit the essential signaling co-receptor IL-18 beta or mediate pro-inflammatory activity
- IL-37 also binds to IL-18 binding protein (IL-18BP) and enhances the antagonistic effects of IL-18BP
- IL-37 forms a trimeric complex with IL-18BP and IL-18R beta, which results in the blockade of IL-18 activity
- Transcripts of IL-37 have been detected in human tissues, such as lung, testis, and colon tumors, as well as some human cell lines
- Applications Reported: This 37D12 antibody has been reported for use in intracellular staining followed by flow cytometric analysis
- Applications Tested: This 37D12 antibody has been pre-titrated and tested by intracellular staining followed by flow cytometric analysis of normal human peripheral blood cells using the Intracellular Fixation & Permeabilization Buffer Set (cat
- 88-8824) and protocol
- Please refer to Best Protocols: Protocol A: Two step protocol for (cytoplasmic) intracellular proteins located under the Resources Tab online
- This can be used at 5 μL (0.06 μg) per test
- The protein encoded by this gene is a member of the interleukin 1 cytokine family
- This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp)
- This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18
- This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2
- Five alternatively spliced transcript variants encoding distinct isoforms have been reported.