4746975
CD2 Mouse anti-Human, BUV395, Clone: RPA-2.10, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD2
Applications
Flow Cytometry
Conjugate
Brilliant Ultraviolet 395
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Isotype
IgG1 κ
Purification Method
Affinity Purified
Description
LFA-2; Lymphocyte function antigen-2; T11/Leu-5; Rosette receptor
Clone
RPA-2.10
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Immunogen
Human Phytohemagglutinin-treated Lymphoblast
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The RPA-2.10 monoclonal antibody specifically binds to CD2
- CD2 is a 50 kDa single-chain transmembrane glycoprotein, also known as LFA-2 or the receptor for sheep erythrocytes
- CD2 belongs to the immunoglobulin superfamily of proteins along with its ligand LFA-3, CD58
- It is present on about 80-90% of human peripheral blood lymphocytes, greater than 95% of thymocytes, all T lymphocytes that form E-rosettes and a subset of NK cells
- CD2 plays a role in T-cell signaling and in lymphocyte adhesion
- The antibody was conjugated to BD Horizon™ BUV395 which has been exclusively developed by BD Biosciences as an optimal dye for use on a 355nm laser equipped instrument
- With an Ex Max at 348nm and an Em Max at 395nm, this dye has virtually no spillover into any other detector
- BD Horizon™ BUV395 can be excited with a 355nm laser and detected with a 379/28 filter.