CD244.2 (2B4) Monoclonal Antibody (eBio244F4), PE, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-107-38-Each-of-1 | In Stock | ₹ 35,066.00 |
50-107-38 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,066.00
GST (18%): ₹ 6,311.88
Total Price: ₹ 41,377.88
Antigen
CD244.2 (2B4)
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q07763
Gene Symbols
Cd244
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
18106
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
eBio244F4
Conjugate
PE
Gene
Cd244
Gene Alias
2B4; C9.1; Cd244; CD244 long isoform; CD244 natural killer cell receptor 2B4; CD244 short isoform; F730046O15Rik; Ly90; NAIL; natural killer cell receptor; natural killer cell receptor 2B4; NK cell receptor 2B4; NK cell type I receptor protein 2B4; NKR2B4; Nmrk; non MHC restricted killing associated; non-MHC restricted killing associated; Signaling lymphocytic activation molecule 4; SLAM family member 4; SLAMF4
Host Species
Rat
Quantity
200 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a
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Description
- Description: Mouse CD244, also known as 2B4, is a receptor belonging to the CD2 family of proteins involved in non-MHC dependent cytotoxicity
- Expression is found on natural killer (NK) cells and many NKT cells and CD8+ cells
- In C57BL/6 mice, two splice variants exist that differ in the length of the cytoplasmic domain
- The long form functions in an inhibitory manner through signaling through SHP-2, while the short form functions in an activating manner
- The ligand for CD244 is CD48 which is expressed on all hematopoietic cells
- Recent data suggests that CD244 interactions with CD48, but not CD2 interaction with CD48, is essential for IL-2-driven expansion and activation of murine NK cells
- Reports show CD244 expression can discriminate hematopoietic progenitors
- Hematopoietic stem cells (HSC) are highly purified as CD150+CD244-CD48- cells while non-self-renewing multipotent hematopoietic progenitors (MPP) are CD244+CD150-CD48- and the most restricted progenitors are CD48+CD244+CD150-
- eBio244F4 was generated against cell lines expressing CD244
- It reacts with the C57BL/6 but not Balb/c due to polymorphisms present in the immunoglobulin V domain of the protein
- The epitope recognized by eBio244F4 is different from that of 2B4; therefore these antibodies do not cross-block the binding to the respective epitopes
- Applications Reported: This eBio244F4 antibody has been reported for use in flow cytometric analysis
- This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing
- The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity
- Alternatively spliced transcript variants encoding different isoforms have been found for this gene.