CD43 Monoclonal Antibody (eBio84-3C1 (84-3C1)), APC, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-3054-Each-of-1 | In Stock | ₹ 27,145.00 |
50-112-3054 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 27,145.00
GST (18%): ₹ 4,886.10
Total Price: ₹ 32,031.10
Antigen
CD43
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
P16150
Gene Symbols
SPN
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6693
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
eBio84-3C1 (84-3C1)
Conjugate
APC
Gene
SPN
Gene Alias
3E8 antigen; A630014B01Rik; B-cell differentiation antigen LP-3; CD43; CD43 cytoplasmic tail; CD43-ct; Galactoglycoprotein; GALGP; gpL115; Leukocyte sialoglycoprotein; leukosialin; leukosianin; LOC101120462; LOW QUALITY PROTEIN: leukosialin; Lsn; Lsn1; Ly48; Ly-48; Lymphocyte antigen 48; sialophorin; sialophorin (gpL115, leukosialin, CD43); sialophorin gpL115; SPN; W3/13 antigen
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
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Description
- Description: The monoclonal antibody ebio84-3C1 reacts with CD43, which is also known as leukosialin, galactoglycoprotein and sialophorin
- CD43 is a sialomucin which like many mucins can have both adhesive and anti-adhesive functions
- Expression of CD43 is found on most leukocytes except resting B lymphocytes
- Proteolytic processing upon activation decreases surface expression
- CD43 is involved in activation of T cells, B cells, NK cells, and monocytes
- The counter-receptor for CD43 is CD169/SIGLEC-1, which is expressed on macrophages
- Applications Reported: This eBio84-3C1 (84-3C1) antibody has been reported for use in flow cytometric analysis
- Applications Tested: This eBio84-3C1 (84-3C1) antibody has been pre-titrated and tested by flow cytometric analysis of human peripheral blood monocytes
- This can be used at 5 μL (0.25 μg) per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser
- Filtration: 0.2 μm post-manufacturing filtered
- CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells
- CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation
- By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic
- CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors
- Expression of CD43 causes induction of functionally active tumor suppressor p53 protein, but in case of p53 and ARF deficiency CD43 promotes tumor proliferation and viability
- CD43 appears to be an important modulator of leukocyte functions
- Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.