50-112-4542
Granzyme M Monoclonal Antibody (4B2G4), eFluor™ 660, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-4542-Each-of-1 | In Stock | ₹ 40,406.00 |
50-112-4542 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,406.00
GST (18%): ₹ 7,273.08
Total Price: ₹ 47,679.08
Antigen
Granzyme M
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
P51124
Gene Symbols
GZMM
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3004
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
4B2G4
Conjugate
eFluor 660
Gene
GZMM
Gene Alias
granzyme M; granzyme M (lymphocyte met-ase 1); GZMM; Hu-Met-1; Lmet1; lymphoctye Met-ase 1; lymphocyte met-ase 1; MET1; Met-1 serine protease; Met-ase; MMET-1; natural killer cell granular protease; RNK-Met-1
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
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Description
- Description: Granzyme M is one of five granzyme serine proteases that have been identified in humans
- These proteins are expressed in the granules of NK cells and cytotoxic T cells, and are critical for the induction of target cell apoptosis through the cleavage of intracellular substrates
- Although not as well characterized as some of the other family members, Granzyme M has been found to exhibit some distinct functions
- These include the non-cytotoxic inhibition of cytomegalovirus replication, induction of apoptosis in tumor cells, and contribution to the TLR4-induced inflammatory process
- Applications Reported: This 4B2G4 antibody has been reported for use in intracellular staining followed by flow cytometric analysis
- Applications Tested: This 4B2G4 antibody has been pre-titrated and tested by intracellular staining followed by flow cytometric analysis of normal human peripheral blood cells using the Intracellular Fixation & Permeabilization Buffer Set (cat
- 88-8824) and protocol
- Please refer to Best Protocols: Protocol A: Two step protocol for (cytoplasmic) intracellular proteins located under the Resources Tab online
- This can be used at 5 μL (0.125 μg) per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- Cleaves peptide substrates after methionine, leucine, and norleucine
- Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin
- Promotes caspase activation and subsequent apoptosis of target cells.