CD275 (B7-H2) Monoclonal Antibody (MIH12), Functional Grade, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-112-8805-Each-of-1 | In Stock | ₹ 32,930.00 |
50-112-8805 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,930.00
GST (18%): ₹ 5,927.40
Total Price: ₹ 38,857.40
Antigen
CD275 (B7-H2)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7.2
Gene Accession No.
O75144
Gene Symbols
ICOSLG
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23308
Content And Storage
4° C
Form
Liquid
Applications
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Neutralization
Clone
MIH12
Conjugate
Functional Grade
Gene
ICOSLG
Gene Alias
AU044799; B7 homolog 2; B7 homologue 2; B7h; B7H2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP1; B7RP-1; BG071784; CD275; GI50; GL50; GL50-B; ICOS ligand; ICOSL; ICOS-L; ICOSLG; inducible T-cell costimulator ligand; inducible T-cell co-stimulator ligand; KIAA0653; LICOS; Ly115l; mKIAA0653; RGD1562791; transmembrane protein B7-H2 ICOS ligand
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
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Description
- Description: The MIH12 monoclonal antibody reacts with human B7RP-1, also known as B7h, B7-H2, GL50 and ICOS Ligand
- B7RP-1, a member of the B7 family, has a predicted molecular weight of approximately 40 kDa and belongs to the Ig superfamily
- Human B7RP-1 is expressed by activated monocytes/macrophages
- B7RP-1 binds to the ICOS molecule (AILIM, CRP-1) expressed by activated T cells
- The interaction of ICOS/B7RP-1 plays an important role in the T cell costimulation pathway
- Applications Reported: This MIH12 antibody has been reported for use in flow cytometric analysis, and immunohistology staining of frozen tissue sections
- The MIH12 monoclonal antibody has also been demonstrated to block the co-stimulatory function of B7RP-1 including the inhibition of T-cell proliferation and IL-10 production
- Applications Tested: The MIH12 antibody has been tested by flow cytometric analysis of normal human peripheral blood monocyte-derived dendritic cells
- This can be used at less than or equal to 1 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay
- Storage and handling: Use in a sterile environment
- Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and cells of the peripheral tissue that binds to the inducible co-stimulator receptor (ICOS)
- ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function
- ICOSL is expressed on monocytes, dendritic cells and B cells and can be induced by inflammatory stimuli in peripheral tissue
- Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion.