50-112-9330
CD169 (Siglec-1) Monoclonal Antibody (SER-4), PE, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each | 50-112-9330-Each | In Stock | ₹ 11,805.85 |
50-112-9330 - Each
In Stock
Quantity
1
Base Price: ₹ 11,805.85
GST (18%): ₹ 2,125.053
Total Price: ₹ 13,930.903
Antigen
CD169 (Siglec-1)
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q62230
Gene Symbols
SIGLEC1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
20612
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
SER-4
Conjugate
PE
Gene
SIGLEC1
Gene Alias
Cd169; dJ1009E24.1; macrophage receptor; p210; pSn; SA; SER; sheep erythrocyte receptor; sialic acid binding Ig like lectin 1; sialic acid binding Ig-like lectin 1, sialoadhesin; Sialic acid-binding Ig-like lectin 1; sialic acid-binding immunoglobulin-like lectin 1; sialoadhesin; SIGLEC1; Siglec-1; SN
Host Species
Rat
Quantity
25 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
Related Products
Description
- Description: The SER-4 monoclonal antibody reacts with mouse CD169, which is also known as Sialoadhesin and Siglec-1
- CD169 is a 185-kDa member of the Siglec family of adhesion and endocytic receptors that recognize sialylated glycans
- This receptor is expressed on a subset of macrophages that are found with high frequency in the spleen, liver, lymph node, and bone marrow
- CD169 can also be detected on monocytes in the bone marrow and periphery
- This receptor plays a role in cell-cell adhesion, as well as internalization of sialylated virus and bacteria
- This endocytic pathway allows CD169+ macrophages to present lipid antigens to iNKT cells, thereby leading to their activation
- Studies have also demonstrated that direct interaction of CD169 with regulatory T cells inhibits their proliferation
- The SER-4 antibody has been reported to have antagonist activity
- Applications Reported: This SER-4 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This SER-4 antibody has been tested by flow cytometric anaylsis of mouse bone marrow cells
- This can be used at less than or equal to 1 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions
- Family members include sialoadhesin, CD22 and CD33
- Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours.