CD1a Monoclonal Antibody (HI149), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-113-0731-Each-of-1 | In Stock | ₹ 31,595.00 |
50-113-0731 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,595.00
GST (18%): ₹ 5,687.10
Total Price: ₹ 37,282.10
Antigen
CD1a
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
P06126
Gene Symbols
CD1A
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
909
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
HI149
Conjugate
PerCP-eFluor 710
Gene
CD1A
Gene Alias
CD1; CD1 antigen; CD1.1; CD1A; CD1A antigen, a polypeptide; CD1a molecule; cd1a1; CD1A1 antigen; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; FCB6; HTA1; hTa1 thymocyte antigen; R4; T6; T-cell surface antigen T6/Leu-6; T-cell surface glycoprotein CD1a
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins
- These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity
- Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification
- CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta 2 microglobulin
- CD1a is expressed by cortical thymocytes, Langerhan's cells and by interdigitating cells
- CD1a is also expressed by some malignancies of T cell lineage and in histiocytosis X
- CD1a is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues
- CD1a is structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin
- The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells
- The human genome contains five CD1 family genes organized in a cluster on chromosome 1
- The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands
- CD1a localizes to the plasma membrane and recycles vesicles of the early endocytic system
- At least five CD1 genes (CD1a, b, c, d, and e) are identified
- Alternatively spliced transcript variants of CD1a have been observed, but their biological validity have not been determined.