Granzyme B Monoclonal Antibody (GB12), PE, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-113-7520-Each-of-1 | In Stock | ₹ 45,212.00 |
50-113-7520 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,212.00
GST (18%): ₹ 8,138.16
Total Price: ₹ 53,350.16
Antigen
Granzyme B
Classification
Monoclonal
Concentration
0.15 mg/mL
Formulation
PBS with 10% sucrose, 4mg/mL BSA and 0.1% sodium azide
Gene Accession No.
P10144
Gene Symbols
GZMB
Immunogen
Human Granzyme B.
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry
Clone
GB12
Conjugate
PE
Gene
GZMB
Gene Alias
AI553453; C11; Cathepsin G-like 1; CCP1; CCP-1/C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; Ctla1; Ctla-1; CTSGL1; cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme-2; GranzymeB; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; Gzmb; HLP; human lymphocyte protein; Human lymphocyte protein (Hlp); Lymphocyte protease; Natural killer cell protease 1; OTTHUMP00000028189; RNKP-1; SECT; T-cell serine protease 1-3E
Host Species
Mouse
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
3002
Content And Storage
4° C
Form
Liquid
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Description
- According to the literature this antibody recognizes granzyme B1
- Each lot is tested by flow cytometry using peripheral blood leukocytes
- Based on this testing it is recommended that 5 μL of antibody be used per 1 x 10^6 cells
- For R-PE conjugates excitation 488 nm/peak emission 575 nm
- Matching isotype control is available: Ms IgG1 R-PE #MG104
- Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells
- Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells
- Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells
- The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis
- Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis
- Granzyme B can also act through a mitochondrial apoptosis pathway by cleaving the Bid protein
- Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells
- A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified.