FAS Monoclonal Antibody (DX2), Pacific Blue™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each | 50-113-8131-Each | In Stock | ₹ 29,071.85 |
50-113-8131 - Each
In Stock
Quantity
1
Base Price: ₹ 29,071.85
GST (18%): ₹ 5,232.933
Total Price: ₹ 34,304.783
Antigen
FAS
Classification
Monoclonal
Conjugate
Pacific Blue
Gene
FAS
Gene Alias
AI196731; ALPS1A; APO1; APO-1; Apo1 antigen; Apo-1 antigen; APO-1 cell surface antigen; Apo-1 Fas; apoptosis antigen 1; apoptosis signaling receptor FAS; apoptosis-mediating surface antigen FAS; APT1; CD95; CD95 antigen; FAS; Fas (TNF receptor superfamily member 6); Fas (TNF receptor superfamily member); Fas (TNF receptor superfamily, member 6); Fas AMA; Fas antigen; Fas antigen (ATP1); Fas cell surface death receptor; Fas receptor; FAS1; FASLG receptor; FASTM; lpr; lymphoproliferation; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; TNF receptor superfamily member 6; TNFR6; Tnfrsf6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 26; Tumor necrosis factor receptor superfamily, member 6
Host Species
Mouse
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
355
Content And Storage
4° C
Form
Liquid
Applications
Flow Cytometry
Clone
DX2
Formulation
PBS with BSA and 0.1% sodium azide
Gene Accession No.
P25445
Gene Symbols
FAS
Immunogen
Human CD95.
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily
- FAS also exists in a soluble form that weight approximately 26kDa
- Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases
- The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis
- FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells
- At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described
- The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform
- The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer
- It is also assumed that induction of apoptosis through FAS ligand pathway is predominantly involved in anti-viral immune responses.