CD217 (IL-17Ra) Monoclonal Antibody (424LTS), APC, eBioscience™, Invitrogen™

Description

• Description: The 424LTS monoclonal antibody reacts with and blocks IL-17A binding to human interleukin 17 receptor A (IL-17RA, IL-17R)
• IL-17RA is a type I membrane protein of approximately 96 kDa (866 amino acids) and is involved in inflammatory responses to IL-17A, IL-17F and IL-17AF heterodimer
• It forms heterodimeric complexes with several other members of its receptor family, including IL-17RC for IL-17A and IL-17F signaling and IL-17RC for IL-17E (IL-25) signaling
• IL-17RA is ubiquitously expressed, but in leukocytes its expression is elevated on granulocytes and monocytes
• Applications Reported: This 424LTS antibody has been reported for use in flow cytometric analysis
• Applications Tested: This 424LTS antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells
• This can be used at 5 μL (0.25 μg) per test
• A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
• Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
• Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser
• Filtration: 0.2 μm post-manufacturing filtered
• Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes
• It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils
• IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F
• IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis
• Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections.