50-155-7126
BHC110/LSD1 Polyclonal Antibody, Bethyl Laboratories
Manufacturer: Bethyl Laboratories, Inc
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-155-7126-Each-of-1 | In Stock | ₹ 12,384.35 |
50-155-7126 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 12,384.35
GST (18%): ₹ 2,229.183
Total Price: ₹ 14,613.533
Antigen
BHC110/LSD1
Classification
Polyclonal
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.
O60341
Gene Symbols
KDM1A
Immunogen
Between 825 and C-term
Quantity
20 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry, Western Blot
Conjugate
Unconjugated
Gene
KDM1A
Gene Alias
AOF2, LSD1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23028
Content And Storage
4° C
Form
Liquid
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Description
- The recommended shelf life for this product is 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predict LSD1 is a histone demethylase that specifically demethylates ′Lys-4′ of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor
- LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain
- This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase
- It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed
- LSD1 demethylates both mono- and tri-methylted ′Lys-4′ of histone H3
- This protein may play a role in the repression of neuronal genes
- Alone, it is unable to demethylate H3 ′Lys-4′ on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity
- It may also demethylate ′Lys-9′ of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes
- Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.