50-157-1277
CD45 Recombinant Rabbit Monoclonal Antibody (BL-178-12C7), Bethyl Laboratories
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-157-1277-Each-of-1 | In Stock | ₹ 48,474.74 |
50-157-1277 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,474.74
GST (18%): ₹ 8,725.453
Total Price: ₹ 57,200.193
Antigen
CD45
Classification
Recombinant Monoclonal
Conjugate
Unconjugated
Gene
PTPRC
Gene Alias
B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200; CD45 antigen; T200 glycoprotein; T200 leukocyte common antigen; protein tyrosine phosphatase; receptor type; c polypeptide; receptor-type tyrosine-protein phosphatase C; HCD45
Host Species
Rabbit
Purification Method
Purified
Regulatory Status
RUO
Gene ID (Entrez)
5788
Content And Storage
4° C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Clone
BL-178-12C7
Formulation
BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
Gene Accession No.
P08575
Gene Symbols
PTPRC
Immunogen
Between 1254 and 1304
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
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Description
- The recommended shelf life for this product is 1 year from date of receipt
- Application Note: For ICC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommende CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes
- CD45 is absent on non-hematopoietic cell lines, normal and maligt, non-hematopoietic tissues
- CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases
- CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains
- CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells
- CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell
- CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling
- CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.